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Sign Up for FORCE NewslettersInformation for People with an Inherited Mutation
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Inherited mutations in the gene cause . Other names for include:
- Hereditary Nonpolyposis Colorectal Cancer ()
- Muir-Torre syndrome, which refers to a subset of in which people have an increased risk of developing rare skin tumors.
People with an inherited mutation have an increased risk for many cancers, especially of the large intestine (the colon and the rectum) and uterus (endometrium). Expert guidelines include estimates of the lifetime cancer risks for people with mutations. These are updated yearly based on new research.
People with an mutation have options for screening, prevention and treatment of . There are expert guidelines and clinical trials that focus on:
- screening and early detection
- risk-reduction
- treatment
Mutations in cause by affecting a nearby gene called , which is also linked to . Cancer risks and risk-management recommendations are similar for people with mutations in or .
There may be other medical concerns, including a rare childhood disease known as “constitutional (CMMRD),” which can happen in people who inherit a mutation in both copies of their gene.
Each of these topics is outlined in more detail in the sections highlighted below.
More Information on Mutations
Cancer Risks
Cancer risk estimates are updated based on the latest research. Read about the lifetime risk for different cancers in people with and inherited mutation.
Risk Management Options
Read about the latest expert guidelines for cancer screening and prevention for people with an mutation. Learn about research studies enrolling high-risk patients.
Cancer Treatment Options
Tumor testing and genetic testing can provide additional clues about which treatments may work best for your cancer. People who test positive for an mutation may have additional treatment or clinical trial options available to them.
Other Considerations
People who inherit a mutation in both copies of their gene—one from each parent—have a rare disease known as "constitutional ." Learn additional information about inherited mutations.
More Resources
Participate in Prevention Research
The screening and prevention studies below are enrolling people with mutations. To search for more studies, visit our Search and Enroll Tool.
Cancer Prevention Vaccine (Nous-209) for People with Lynch Syndrome
Clinicaltrials.gov identifier:
NCT05078866
Testing A Combination Of Vaccines For Cancer Prevention In Lynch Syndrome
Clinicaltrials.gov identifier:
NCT05419011
Early Detection of Colorectal Cancer for People with Lynch Syndrome
Clinicaltrials.gov identifier:
NCT05410977
Clinicaltrials.gov identifier:
NCT05396846
Studying the Use of Naproxen and Aspirin for Cancer Prevention in People with Lynch Syndrome
Clinicaltrials.gov identifier:
NCT05411718
Pancreatic Cancer Screening Study (CAPS5)
Clinicaltrials.gov identifier:
NCT02000089
Participate in Treatment Research
The treatment studies below are enrolling people with mutations. To search for more studies, visit our Search and Enroll Tool.
Testing Immunotherapy Treatments for Recurrent Endometrial Cancer
Clinicaltrials.gov identifier:
NCT05112601
Nivolumab and Relatlimab in Advanced MSI-H Cancers Resistant to Prior PD-L1 Inhibitor
Clinicaltrials.gov identifier:
NCT03607890
Clinicaltrials.gov identifier:
NCT02997228
Watch Our Webinar for People with
Webinar: What's new for people with Lynch syndrome?